Overview of Picked Chemical Compounds and Intermediates
Overview of Picked Chemical Compounds and Intermediates
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one. Pharmaceutical Intermediates
Bortezomib Acid Impurity: That is an impurity relevant to bortezomib, a proteasome inhibitor Utilized in the treatment method of many myeloma. Its synthesis or examine is vital for ensuring the purity and basic safety from the drug.
Abiraterone Acetate Intermediate (CAS NO. 122111-01-seven): A precursor inside the synthesis of abiraterone acetate, a drug used in the treatment of prostate cancer by inhibiting androgen manufacturing.
Imatinib Intermediate (CAS NO. 152460-ten-1): A key compound during the synthesis of imatinib, a drug that targets distinct varieties of most cancers, which includes Persistent myelogenous leukemia (CML).
Docetaxel Intermediate: A compound Utilized in the synthesis of docetaxel, a chemotherapy medication that treats different cancers such as breast, lung, and prostate cancer.
two. Chemical Impurities and Byproducts
GeMcitabine Intermediates (T6, T9, 8): These are intermediates while in the synthesis of gemcitabine, an anti-most cancers drug. Their examine is important for optimizing the generation process and guaranteeing high purity.
Lapatinib Intermediate (CAS NO. 231278-84-five): Lapatinib is made use of to treat breast most cancers, and these intermediates are linked to its production.
Fulvestrant Intermediates: Fulvestrant is undoubtedly an estrogen receptor N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine antagonist used in the cure of breast most cancers. A variety of intermediates assist in the synthesis of this drug.
Paclitaxel Facet Chain Acid (CAS NO. 949023-sixteen-9): This intermediate is used in the synthesis of paclitaxel, a chemotherapy drug powerful in managing cancers such as ovarian, breast, and lung cancer.
3. Other Notable Compounds
Irinotecan Hydrochloride Trihydrate (CAS NO. 136572-09-3): A chemotherapy drug used in the remedy of colorectal most cancers and little cell lung most cancers.
three-Amino-one-hydroxyadamantane (CAS 702-eighty two-nine): This compound is involved in the synthesis of adamantane derivatives, which have numerous apps, which include antiviral properties.
Vildagliptin Intermediates: Used in the production of vildagliptin, an oral drug for kind 2 diabetes that inhibits the enzyme DPP-4 to regulate blood sugar amounts.
4. Miscellaneous Compounds
D-Gluconic Acid δ-Lactone (CAS NO. 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2 61259-48-one): This compound is linked to the synthesis of assorted gluconic acid derivatives, which are Employed in food, pharmaceutical, and industrial applications.
Canagliflozin Intermediate two: A precursor within the synthesis of canagliflozin, a medication made use of to deal with style two diabetes by inhibiting sodium-glucose co-transporter 2 (SGLT2).